Robert Scott Illingworth

The paper identifies H3K115ac enrichment at fragile nucleosomes in promoters and enhancers, suggesting its role in nucleosome destabilization and regulatory element identification.

This study shows that respiratory viral infection primes lung epithelial cells to enhance antigen presentation, leading to improved T cell responses to subsequent antigens.

This study shows that H2AK119ub, catalyzed by PRC1, prevents ectopic gene activation by transcription factors during neural differentiation, ensuring proper cell fate restriction in the developing forebrain.

This study investigates the role of PRC2 in endodermal differentiation by analyzing its impact on gene repression and lineage fidelity in a stem cell model.

This study shows ALDH1A3 and ACSS2 coordinate acetaldehyde-acetyl-CoA metabolism with histone acetylation in melanoma, contributing to transcriptional heterogeneity and drug resistance.

This study identifies DAXX's role in maintaining heterochromatin structure in ESCs by recruiting PML and SETDB1, and shows its importance for genome integrity and pluripotency.

Coolpup.py provides a versatile and efficient tool for pile-up analysis of Hi-C data, enabling robust detection of genomic loops and novel insights into 3D genome organization.

The paper identifies PARP1-mediated chromatin unfolding as a mechanism for long-range enhancer activation at the Shh locus in neural progenitor cells.