Michael D. Lewis

This study shows that intermittent posaconazole treatment does not prevent cardiac and digestive tract pathologies in a chronic Chagas disease mouse model, even with high parasite burden reduction.

This study establishes a hamster model of Trypanosoma cruzi infection using bioluminescence imaging, revealing chronic tissue pathology and motor dysfunction not seen in mice.

The paper describes a panel of bioluminescent and fluorescent Trypanosoma cruzi strains to study Chagas disease, enabling real-time monitoring of infection dynamics and drug screening.

The paper presents an improved genome assembly of Trypanosoma cruzi and reveals a unique genomic structure involving subtelomeric regions and retrotransposons contributing to antigenic variation.

This paper introduces a cost-effective method for analyzing pathogen genetic variation directly from host/vector material, demonstrating its ability to distinguish parasite strains and correlate genetic with geographic distances.