Shiromani Jayawardhana

This study shows that intermittent posaconazole treatment does not prevent cardiac and digestive tract pathologies in a chronic Chagas disease mouse model, even with high parasite burden reduction.

This study shows statins do not reduce parasite burden in a mouse model of Trypanosoma cruzi infection, suggesting clinical trials for trypanocidal activity are unjustified.

This study establishes a hamster model of Trypanosoma cruzi infection using bioluminescence imaging, revealing chronic tissue pathology and motor dysfunction not seen in mice.

The paper describes a panel of bioluminescent and fluorescent Trypanosoma cruzi strains to study Chagas disease, enabling real-time monitoring of infection dynamics and drug screening.