Ze-Hui Ren

This study uses nanopore direct RNA sequencing to analyze how m6A modifications and poly(A) tail dynamics influence RNA degradation kinetics and isoform-specific decay.

This study introduces SingleMod, a deep learning model for m6A modification mapping using single-molecule RNA sequencing, revealing m6A heterogeneity and species-specific distribution patterns.

The paper identifies and characterizes m6A sites across human and mouse cell lines and tissues, revealing distinct features of high and low consistency m6A sites and their associations with gene regulation.