Hongxuan Chen

OpenBase provides a framework for high-accuracy detection of diverse non-canonical DNA bases using nanopore sequencing through standardized training data and deep learning models.

This study identifies WTAP as a p65-regulated m6A writer that promotes inflammation via phase separation and m6A modification, offering a therapeutic target for hyperinflammation.

The paper identifies and characterizes m6A sites across human and mouse cell lines and tissues, revealing distinct features of high and low consistency m6A sites and their associations with gene regulation.