David A. Constant

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.

This study identifies IRF6's role in regulating intestinal epithelial cell development and innate immunity, showing it modulates antiviral responses and maintains barrier function.

The paper develops deep learning models trained on synonymous variant datasets to predict and optimize protein expression in E. coli.