Author

Timothy J. Nice

Oregon Health & Science UniversityORCID 0000-0002-4471-7666Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

David A. ConstantiD· 3 shared Gargi MishraiD· 2 shared Ram SavaniD· 2 shared Shelby R. MaddeniD· 2 shared Adam Lacy‐HulbertiD· 1 shared Adelle P. McFarlandiD· 1 shared Alec M. GriffithiD· 1 shared Alexis R. GibsoniD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersImmunology

David A. ConstantORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintJun 10, 2026

Lineage-specific chromatin poising enforced by ETS-IRF composite elements determines the divergent interferon responses of plasmacytoid dendritic cells and epithelial cells

Gargi Mishra, Snehal Ozarkar, Yo Okamura…·Ram Savan

This paper identifies lineage-specific chromatin accessibility differences at IFN gene loci in pDCs and epithelial cells, revealing ETS-IRF composite elements as key regulators of divergent interferon responses.

1 citation

humanATAC-seq

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ImmunologybioRxivPreprintAug 25, 2025

Plasmacytoid dendritic cells in the intestine preferentially produce interferon lambda at homeostasis contributing to tonic localized innate immune responses

David A. Constant, Jacob A. Van Winkle, Philip A Norwood…·Timothy J. Nice

This study identifies intestinal plasmacytoid dendritic cells (pDC) as a major source of homeostatic IFN-λ and shows TGF-β regulates their IFN production.

2 citations

mousebulk RNA-seq

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ImmunologyMucosal ImmunologyPeer-reviewedApr 9, 2024

Interferon Regulatory Factor 6 Determines Intestinal Epithelial Cell Development and Immunity

Austin P. Wright, Sydney Harris, Shelby R. Madden…·Timothy J. Nice

This study identifies IRF6's role in regulating intestinal epithelial cell development and innate immunity, showing it modulates antiviral responses and maintains barrier function.

14 citations

mousescRNA-seq

𝕏 PostBluesky