Gerald R. Crabtree

This paper develops KAT-TCIPs to induce cell death in diffuse large B cell lymphoma by redirecting p300 and CBP to activate programmed cell death genes repressed by BCL6.

This paper introduces DD-CIPs, bivalent molecules that induce DNA damage response and apoptosis in cancer cells, showing efficacy against PARPi-resistant cancers.

The paper investigates how synaptic activity rapidly alters BAF complex composition and function in neurons, revealing phosphorylation and chromatin remodeling effects within minutes.

The paper develops bivalent molecules that convert kinase inhibitors into activators of proapoptotic genes, achieving selective killing of DLBCL cells with low cytotoxicity.

The paper investigates brain pH and lactate levels in animal models of neuropsychiatric disorders, finding decreased pH and increased lactate levels as common features across multiple models.

This study shows that increased ACTL6A occupancy in BAF chromatin remodelers drives SCC initiation by enhancing TEAD-YAP binding and counteracting polycomb repression.

This study shows that the BAF complex both antagonizes and promotes polycomb-mediated repression by redistributing polycomb complexes across the genome in embryonic stem cells.

The paper shows that switching from npBAF to nBAF chromatin complexes controls cell cycle exit and promotes neural differentiation in developing mouse brains.

This study shows that nucleosome turnover can establish varied H3K79 methylation states without active demethylation.

The paper confirms lower brain pH in schizophrenia and bipolar disorder patients and shows it persists in animal models, suggesting it is a pathophysiological feature rather than an artifact.