Sabin A. Nettles

This paper develops KAT-TCIPs to induce cell death in diffuse large B cell lymphoma by redirecting p300 and CBP to activate programmed cell death genes repressed by BCL6.

This paper develops a small molecule, TRAP-1, that activates mutant p53 by forming a ternary complex with BRD4, leading to p53 target gene upregulation and inhibition of cancer cell growth.

The paper investigates how synaptic activity rapidly alters BAF complex composition and function in neurons, revealing phosphorylation and chromatin remodeling effects within minutes.

The paper develops bivalent molecules that convert kinase inhibitors into activators of proapoptotic genes, achieving selective killing of DLBCL cells with low cytotoxicity.

This study identifies a functional interaction between MeCP2 and TOP2β in neurons, showing MeCP2 inhibits TOP2β activity at long genes, which may contribute to neurodevelopmental disorders.

The paper shows NSD1 deposits H3K36me2 to pattern non-CG DNA methylation in neurons, linking this to neurodevelopmental disorders.

This study shows that DNMT3A mutations cause behavioral and epigenomic changes in mice, similar to human neurodevelopmental disorders, by disrupting non-CG DNA methylation.