Author

Rui‐Hua Xu

Zhengzhou UniversityORCID 0000-0001-9771-8534Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Genomics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2

Frequent Co-Authors

lidong wangiD· 2 shared Ling-Ling Lei· 2 shared Miao ZhaoiD· 2 shared pengwei xingiD· 2 shared Xin SongiD· 2 shared Xingqi CheniD· 2 shared Ai-Li Li· 1 shared Alyssa N. HoiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

lidong wangORCID

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4 papers

Recent·Most cited

Cancer BiologyCommunications BiologyPeer-reviewedAug 18, 2026

HER2 Prognostic Significance and Therapeutic Implications in Gastric Cardia Adenocarcinoma: Insights from Multi-Omics Profiling

lidong wang, pengwei xing, Xue-Ke Zhao…·Xingqi Chen

This study identifies HER2 as a prognostic marker in GCA and suggests anti-inflammatory and immune checkpoint inhibition as therapeutic strategies for HER2-negative patients.

DOI 10.1038/s42003-026-10792-x

humanwhole-exome sequencing

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ImmunologyNature CommunicationsPeer-reviewedNov 5, 2024

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

Haiyan Zhang, Xiao-Jing Luo, Wei Yang…·Jiajie Hou

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

38 citationstop 3%

mousehuman

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Cancer BiologybioRxivPreprintJan 20, 2024

Tirzepatide restricts obesity-related tumor growth by reversing metabolic dysregulation and rescuing CD8+ T cell function

Elaine M. Glenny, Michael F. Coleman, Genevieve T. Clutton…·Stephen David Hursting

This study shows tirzepatide reduces obesity-related tumor growth by improving metabolism and restoring CD8+ T cell function without directly targeting cancer cells.

18 citations

mouseexperimental assay

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GenomicsNature CommunicationsPeer-reviewedNov 11, 2021

Extrachromosomal DNA is associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma

Xueke Zhao, Pengwei Xing, Xin Song…·Lidong Wang

The paper investigates extrachromosomal DNA (ecDNA) in gastric cardia adenocarcinoma, finding associations with chromothripsis, DNA damage, and prognosis based on oncogene amplicons.

57 citationstop 2%

humanwhole-exome sequencing

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