Thomas C. Friedrich

This study shows that dry Jersey cows are highly susceptible to H5N1 HPAIV, with virus dose affecting mastitis severity in udder quarters.

This study infects pregnant rhesus macaques with Spondweni virus and finds placental pathology without fetal harm, contrasting with ZIKV-DAK-induced fetal demise.

This study shows bovine-derived H5N1 viruses face evolutionary constraints in ferrets, limiting adaptation for efficient mammalian transmission despite robust replication.

This study examines influenza A virus evolution during household transmission, finding weak selection and stochastic processes dominate, with no clear evidence of antigenic variant selection during transmission.

This study quantifies how exposure route, rather than dose, influences SARS-CoV-2 infection kinetics in non-human primates using a large meta-analysis of challenge experiments.

This study shows that prenatal Zika virus exposure in macaques disrupts social-emotional development and visual function, independent of viral factors or maternal immunity.

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

This study investigates the pathogenicity and transmissibility of a bovine-derived HPAI H5N1 B3.13 virus in pigs, finding susceptibility but limited replication and no transmission.

This study infects pregnant rhesus macaques with clade IIb Mpox virus and finds vertical transmission to the fetus and adverse pregnancy outcomes.

This study shows that potent antibody-dependent cellular cytotoxicity (ADCC) by a V2-specific antibody is insufficient to protect macaques against SIV challenge, but reduced viral loads were observed with a neutralization-sensitive SIV variant.

This study investigates Wolbachia's effect on ZIKV infection in Ae. aegypti using transcriptomics and viral sequencing, finding no clear transcriptional profile or evidence of ZIKV escape.

This study uses barcoded Zika virus to track genetic bottlenecks during transmission in vitro and in mosquitoes, showing stochasticity in viral dissemination.

The paper identifies two novel SHFVs in wild primates, showing high genetic diversity and signs of positive selection, suggesting adaptive potential.