Author
TU Dortmund UniversityORCID 0000-0001-9832-3534Unclaimed ORCID profile · follow to get notified of new preprints
5 papers
Recent·Most cited
Joel Cyrille Brenner, Linda C. Zirden, Lana Buzuk…·Doris Hellerschmied
This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.
Eman Zaffar, Julio Vieyto‐Nuñez, Katerina Pravi…·Elsa Sánchez‐García
The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.
Dan Albers, Sofya Novikova, Julio Vieyto‐Nuñez…·Mirja Harms
This study shows GPR15LG binds CXCR4, enhancing CXCL12-induced signaling and promoting cell migration in immune and cancer cells.
Jan Lawrenz, Lukas Wettstein, Armando Rodríguez…·Jan Münch
This paper identifies Trypstatin, a Kunitz-type protease inhibitor that inhibits TMPRSS2 and related proteases, showing broad-spectrum antiviral activity against SARS-CoV-2, influenza, and other respiratory viruses.
Matthew Day, Bilal Tetik, Milena Parlak…·Dominik Boos
This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.