Markus Kaiser

The paper introduces cellmig, a Bayesian tool for quantifying cell migration velocity with uncertainty, improving reproducibility and biological insight in high-throughput assays.

This study shows that NbRD21 protease regulates receptor-like kinase homeostasis in Nicotiana benthamiana by affecting their post-translational processing and endocytic recycling.

The paper introduces polychrome activity profiling using fluorescent probes to distinguish Cys proteases and their isoforms in plants by exploiting differential probe affinity.

This study shows that eliminating polyphenol oxidase in Nicotiana benthamiana improves recombinant protein yield, purity, and native-state integrity during extraction.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

The paper identifies a mechanism by which misfolded Golgi membrane proteins are ubiquitinated and degraded by the proteasome to prevent Golgi fragmentation.

This study identifies TPS5/6/7 as T6P sensors that inhibit SnRK1 activity to coordinate plant growth with sugar availability in Arabidopsis thaliana.

This study shows ATXN3 helps restore lysosomal function after damage by targeting K48-K63-branched ubiquitin chains on regenerating lysosomes.

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

This study uses reactivity proteomics to analyze ATP-induced changes in Arabidopsis proteomes, revealing conformational shifts and metabolite-protein interactions.

This study identifies galactosyrin, an iminosugar produced by Pseudomonas syringae, which inhibits plant β-galactosidase and alters host glycobiology to aid infection.

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

This study shows that lack of AtMC1 catalytic activity causes autoimmunity in Arabidopsis, which depends on NLR stability and can be reversed by overexpressing SNIPER1.

This paper identifies molecular glues that stabilize the ChREBP/14-3-3 complex, protecting beta cells from glucolipotoxicity by preventing ChREBP-mediated dedifferentiation.

The paper shows that the subtilase SBT5.2 cleaves flagellin's flg22 epitope, inactivating its immunogenicity and controlling immune responses in plants.

The paper shows that the plant subtilase SBT5.2a cleaves the bacterial cold-shock protein csp22, reducing its immunogenicity and pathogen growth.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

This study shows that archaea can synthesize fatty acids using a newly identified pathway and enzyme complex, providing insights into their evolutionary lipid composition.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

This study identifies flg22-responsive RNA-binding proteins in Arabidopsis, revealing their role in plant immunity and uncovering novel immune components.