Doris Hellerschmied

This study identifies TRIP12 as a proteostasis-responsive E3 ligase that regulates protein stability and the proteostasis network under proteotoxic stress.

The paper identifies a mechanism by which misfolded Golgi membrane proteins are ubiquitinated and degraded by the proteasome to prevent Golgi fragmentation.

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.