Farnusch Kaschani

This study shows that NbRD21 protease regulates receptor-like kinase homeostasis in Nicotiana benthamiana by affecting their post-translational processing and endocytic recycling.

This study identifies Cpi1, a membrane-anchored protease inhibitor in Pseudomonas that inhibits plant PLCPs, enhancing bacterial root colonization by modulating immune responses.

This study shows that eliminating polyphenol oxidase in Nicotiana benthamiana improves recombinant protein yield, purity, and native-state integrity during extraction.

This paper compares the effects of USP7 inhibition and degradation in cancer cells, finding distinct phenotypic and proteomic responses.

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

The paper identifies a mechanism by which misfolded Golgi membrane proteins are ubiquitinated and degraded by the proteasome to prevent Golgi fragmentation.

This study identifies TPS5/6/7 as T6P sensors that inhibit SnRK1 activity to coordinate plant growth with sugar availability in Arabidopsis thaliana.

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

The paper shows that MTBP allosterically activates Cdk8-CycC kinase activity through distinct mechanisms from Med12, enabling substrate-specific phosphorylation and impacting cancer biology.

This study uses reactivity proteomics to analyze ATP-induced changes in Arabidopsis proteomes, revealing conformational shifts and metabolite-protein interactions.

This study identifies galactosyrin, an iminosugar produced by Pseudomonas syringae, which inhibits plant β-galactosidase and alters host glycobiology to aid infection.

This study identifies an unusual glycerol-3-phosphate dehydrogenase in Sulfolobus acidocaldarius involved in glycerol degradation, showing its essential role in growth on glycerol.

This study shows that lack of AtMC1 catalytic activity causes autoimmunity in Arabidopsis, which depends on NLR stability and can be reversed by overexpressing SNIPER1.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

The paper shows that the subtilase SBT5.2 cleaves flagellin's flg22 epitope, inactivating its immunogenicity and controlling immune responses in plants.

The paper shows that the plant subtilase SBT5.2a cleaves the bacterial cold-shock protein csp22, reducing its immunogenicity and pathogen growth.

This study identifies HTRA1 as a non-autonomous protein quality control factor that inhibits tau aggregate propagation by interfering with multiple steps of the spreading process.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

This study identifies novel anti-TB pro-drugs based on α-aminooxyacetic acid that are effective against M. tuberculosis and show low cytotoxicity.

This study shows TopBP1 interacts with GINS via two distinct sites to support replication origin firing and predicts coordination of molecular processes in origin activation.

This paper develops SNAP-PROTACs to induce degradation of SNAP-fusion proteins, enabling selective depletion and functional analysis of target proteins.

The paper reports cryoEM structures of the Pex1/Pex6 ATPase complex from yeast, revealing how it translocates substrates through conformational changes and mechanical force propagation.

This study identifies flg22-responsive RNA-binding proteins in Arabidopsis, revealing their role in plant immunity and uncovering novel immune components.