Author

Linda C. Zirden

University of CologneORCID 0000-0003-2635-757XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Farnusch KaschaniiD· 3 shared Markus KaiseriD· 3 shared Simon PoepseliD· 3 shared Egor A. PavlenkoiD· 2 shared Juliane Renn· 2 shared Alexander RoeschiD· 1 shared Alexandra Hommel· 1 shared Ankush SinghaliD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

Farnusch KaschaniORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 2, 2026

Differences in substrate engagement and Retinoblastoma protein (RB) binding of human KDM5A and KDM5B

Till Ruengeler, Egor A. Pavlenko, Fabian Basler…·Simon Poepsel

This study compares the demethylase activity, nucleosome engagement, and RB binding of KDM5A and KDM5B, revealing differences in their interactions and enzymatic behavior.

DOI 10.64898/2026.04.30.721888

humanChIP-seq

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BiochemistryNature Structural & Molecular BiologyPeer-reviewedJul 14, 2025

Conformational plasticity of a BiP-GRP94 chaperone complex

Joel Cyrille Brenner, Linda C. Zirden, Lana Buzuk…·Doris Hellerschmied

This study characterizes the conformational changes of the BiP-GRP94 chaperone complex and identifies the structural basis of their interaction without co-chaperones.

8 citations

protein structureexperimental assay

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BiochemistryMolecular CellPeer-reviewedSep 19, 2024

Activation of automethylated PRC2 by dimerization on chromatin

Paul Victor Sauer, Egor A. Pavlenko, Trinity Cookis…·Simon Poepsel

The paper reveals a mechanism by which automethylated PRC2 dimerizes on chromatin to allosterically activate another PRC2 protomer for H3K27me3 methylation.

18 citations

ChIP-seqexperimental assay

𝕏 PostBluesky