Chee Wah Tan

This study shows that elderly individuals vaccinated against SARS-CoV-2 maintain neutralizing antibodies against recent variants, with reduced immune imprinting from ancestral variants after booster doses.

The paper develops bioengineered human tonsil organoids (BTOs) to study immune functions, showing they support antigen-specific responses and immune-stromal interactions comparable to native tissues.

A nasal booster vaccine candidate induced cross-clade, durable, systemic and mucosal immunity in mRNA-vaccinated mice, offering superior protection against emerging sarbecoviruses.