Michail Doukas

The paper investigates how inflammation reprograms goblet cells into tumor-initiating cells in colon cancer using single-cell RNAseq and mutation spectrum analysis.

This paper introduces ComSLI, a computational method to map collagen fiber orientation in paraffin-treated tumor tissues, enabling analysis of tumor growth and desmoplastic reactions.

This paper introduces ComSLI, a method to map fiber networks in histology without sample preparation, showing its application across tissues and diseases.

This study identifies two enteric glia classes in health and disease, showing Schwann-like glia persist in HSCR and can be targeted to stimulate neurogenesis in a zebrafish model.

The paper shows that secretory cell lineages, not stem cells, can trigger tumor formation in the context of inflammation and Western-style diets, which are major colon cancer risk factors.