ImmunologybioRxivPreprint
The 3D affinities of the OT-I TCR to foreign and self-antigens predict their 2D affinities and reveal imperfect antigen discrimination
Anna Gesine Huhn, Mikhail A. Kutuzov, Keir Maclean…·Omer Dushek
This paper measures 3D affinities of the OT-I TCR to 19 pMHC complexes and finds they strongly correlate with 2D membrane affinities, revealing imperfect antigen discrimination.
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