James E. Crowe

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

This paper develops and validates nbLIBRA-seq, a method for high-throughput antigen-specific nanobody discovery in immunized alpacas, demonstrating its effectiveness in identifying nanobodies against CD71 and viral antigens.

The paper investigates how IGHV3-53/3-66 antibodies from Omicron BA.1 infection neutralize emerging SARS-CoV-2 variants through structural and mutational analysis.

This study identifies monoclonal antibodies with ACE2-like catalytic activity that may contribute to post-acute sequelae of COVID-19.

The paper identifies a human antibody that neutralizes RSV and hMPV by targeting a novel epitope spanning multiple antigenic sites, showing cross-protection in a mouse model.

The paper isolates glycan-reactive antibodies from HIV-1 vaccine trial participants and finds they neutralize diverse HIV strains and show broad cross-reactivity against other pathogens.

This study identifies a monoclonal antibody that neutralizes HCoV-HKU1 by mimicking sialic acid binding to block receptor engagement.

This paper develops a mouse model of SARS-CoV-2 BA.5 infection that induces fibrotic lung disease and tertiary lymphoid structures, enabling study of acute and post-acute sequelae of COVID-19.

This study uses high-throughput screens in human cells with authentic SARS-CoV-2 virus to identify neutralizing monoclonal antibodies and kinase inhibitors with minimal host toxicity.

This study uses deep mutational scanning to analyze how mutations in the Nipah virus receptor-binding protein affect function, receptor binding, and antibody escape, revealing constrained regions and limited antigenic variation in natural strains.

The paper uses nsEMPEM to analyze polyclonal IgG responses to HA in vaccinated and infected individuals, showing differences in epitope targeting between H1 and H3 subtypes.

This study shows that equine H3N8 vaccine induces broad protection against influenza in multiple animal models, including neutralizing antibodies against diverse viral strains.

This study shows that ZIKV-117, a neutralizing monoclonal antibody, provides complete protection against ZIKV challenge in rhesus macaques at a low dose.

The paper identifies a pan-betacoronavirus antibody that binds the S2 subunit of spike proteins and induces Fc-dependent antiviral responses, offering insights into non-neutralizing antibody protection.

This study shows that Omicron variant-matched boosters after prototype mRNA vaccines induce cross-neutralizing antibodies against SARS-CoV-2 and sarbecoviruses by imprinting prior immune responses.

This paper introduces R4IDs, a method using long-read sequencing to rapidly generate reference datasets for species identification, validated with plant species and simulations.