Author

Sarah L. Gillen

Cancer Research UK Scotland InstituteORCID 0000-0002-0192-864XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Martin BushelliD· 3 shared Joseph A. WaldroniD· 2 shared June Munro· 2 shared Andrew D. CampbelliD· 1 shared Ania WilczynskaiD· 1 shared Barbara Cadden· 1 shared Chiara GiacomelliiD· 1 shared Colin NixoniD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMolecular Biology

Martin BushellORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 10, 2023

eIF4A1 is essential for reprogramming the translational landscape of Wnt-driven colorectal cancers

Joseph A. Waldron, Georgios Kanellos, Rachael C.L. Smith…·Owen James Sansom

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

2 citations

mouseexperimental assay

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Molecular BiologyCancersPeer-reviewedAug 5, 2023

Optimisation of sample preparation from primary mouse tissue to maintain RNA integrity for methods examining translational control

June Munro, Sarah L. Gillen, Louise E. Mitchell…·Martin Bushell

The paper optimizes sample preparation from primary mouse tissue to maintain RNA integrity for translatome analysis techniques like polysome and ribosome profiling.

5 citations

mousebulk RNA-seq

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Molecular BiologyGenome biologyPeer-reviewedOct 6, 2021

Differential regulation of mRNA fate by the human Ccr4-Not complex is driven by CDS composition and mRNA localisation

Sarah L. Gillen, Chiara Giacomelli, Kelly Hodge…·Ania Wilczynska

The paper investigates how the Ccr4-Not complex regulates mRNA fate and protein synthesis through codon composition, amino acid usage, and mRNA localization.

33 citations

humanbulk RNA-seq

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