Martin Bushell

This study identifies Pfk2p as an ATP-dependent RNA unwinding enzyme that modulates cell cycle progression by promoting translation of mitotic genes.

This study identifies how eIF4A1 differentially activates translation based on mRNA features, revealing distinct mechanisms for mRNA selection and inhibition by eFT226 and hippuristanol.

This study shows that increased mRNA translation delays lung adenocarcinoma initiation and creates a vulnerability to MEK inhibitors in KRAS-driven tumors.

This study identifies a mechanism by which antisense oligonucleotides (ASOs) enter cells via scavenger receptors and EPHA2-mediated trafficking to reach nuclear-adjacent endosomes, enhancing their effectiveness.

This study shows that DTX3L ubiquitinates single-stranded DNA and RNA, expanding the known substrates of ubiquitination beyond proteins.

This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.

The paper optimizes sample preparation from primary mouse tissue to maintain RNA integrity for translatome analysis techniques like polysome and ribosome profiling.

This study identifies Mir483 as a growth suppressor and metabolic regulator that antagonizes its host gene Igf2 through IGF1 signaling, revealing a novel mechanism of growth control.

The paper identifies AG-rich RNA sequences in 5'UTRs that regulate eIF4A1 multimerisation to enhance translation of oncogenic mRNAs.

This study shows maternal diet-induced obesity alters fetal cardiac lipidomes and serum lipidomes differently in male and female fetuses, with female hearts showing greater sensitivity.

iMUT-seq maps DSB-induced mutations with high sensitivity and resolution, revealing HR's mutagenic role and its suppression of genomic rearrangements.

The paper identifies a novel chromatin compartment formed by ATM-dependent clustering of damaged TADs, which enhances DNA damage response but increases translocations.

The paper investigates how the Ccr4-Not complex regulates mRNA fate and protein synthesis through codon composition, amino acid usage, and mRNA localization.