Sarah Maslen

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

This study shows TRF2 mediates force-resistant tethering of telomeric DNA repeats, which may be a step in T-loop formation.

This study develops an in vitro system to study SERA6 maturation and validates inhibitors that block malaria parasite egress.

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

The paper investigates how chaperones like Hsp70, Hsp90, and TRiC bind to nascent p53 during translation, showing TRiC's specificity and how mutations affect this process.

This study investigates how GroEL/ES interacts with nascent proteins on ribosomes, showing that GroEL binds and destabilizes substrates, while GroES facilitates partial encapsulation and refolding.

The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.

This study identifies that Salmonella effector kinase SteC is activated by host-mediated phosphorylation at S379, which enhances its kinase activity and promotes actin polymerisation.

This paper identifies the V1H subunit of V-ATPase as a regulator of ATG16L1 recruitment in response to pH gradient disruption, linking V-ATPase function to autophagy activation.

The paper investigates how chaperones coordinate during cotranslational protein folding in bacteria, showing they create a protected space for maturation without destabilizing intermediates.

This study shows TRIM21 can degrade lysine-less substrates without autoubiquitination, revealing a non-canonical ubiquitination mechanism for Trim-Away.

The paper shows Mpe1 interacts with the polyadenylation signal in pre-mRNA to activate CPF and control polyadenylation in yeast.

This paper quantifies protein synthesis and degradation rates in mouse models of neurodegeneration and ageing using metabolic labeling and proteomics, revealing distinct dynamics in disease versus aging.