Andrea Nans

This study shows that C9, a component of membrane attack complexes, forms non-cytolytic intracellular aggregates that promote inflammation and EC activation through aggrephagy and NF-κB activation.

The paper reveals how long-chain heparan sulfate (HS) facilitates paracrine GDNF-GFRα1 signaling by forming a multi-protein complex with RET, essential for signaling in trans but not in cis.

The paper uses cryo-ET and fluorescence microscopy to study ER exit sites in human cells, revealing COPII and COPI vesicle structures and resolving their origin and organisation.

The paper investigates how the human ribosome modulates multidomain protein folding by delaying domain docking, contrasting with bacterial ribosomes.

This study identifies cross-neutralizing mAbs against diverse bat sarbecoviruses and characterizes their conserved epitopes for vaccine design.

This study uses cryo-electron tomography and SIM to analyze vaccinia virus egress, revealing septin and clathrin roles in viral spread and release.

The paper determines the in situ structure of a high-torque bacterial flagellar motor using cryogenic electron microscopy, revealing protein adaptations and universal principles of torque generation.

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

This study uses cryo-EM and biochemical experiments to reveal the mechanism of DNA entry into the cohesin ring, showing how ATP binding and hydrolysis regulate the process.

The paper reports cryo-EM structures of XPF-ERCC1 in DNA-free and DNA-bound states, revealing an auto-inhibited conformation and activation mechanism.