Kai Chen

This study examines the relationship between short-form video use and episodic memory in young adults, finding that higher use is linked to poorer memory for infrequent items.

The paper identifies CRISPR-Cas12a variants with expanded PAM recognition, enabling targeting of ~25% of the human genome.

This study demonstrates that lipid nanoparticle-delivered thermostable Cas9 RNPs achieve high-efficiency genome editing in mouse liver and lung tissues.

The paper shows that engineered GeoCas9 variants enhance genome editing by accelerating DNA unwinding, revealing a new role for the WED domain in this process.

This study engineers self-deliverable CRISPR ribonucleoproteins for efficient genome editing in neural progenitor cells and mouse brain tissue.

The paper traces the evolutionary origin of eukaryotic RNA-guided endonucleases, showing they evolved from a specific clade of bacterial IS607 TnpB enzymes.