Michael Wierer

The paper examines proteomic changes caused by MODY mutations in HNF1A and HNF1B using cell line models, finding suppressed energy metabolism and interferon signaling.

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

The paper identifies Rab2, Syd/dJIP3/4, and RUFY as key regulators of retrograde axonal transport of dense core vesicles in Drosophila, showing distinct roles in DCV motility and sorting.

This paper demonstrates the successful retrieval of palaeoproteomic data from bone fragments in resin-impregnated sediment blocks, enabling microstratigraphic taxonomic identification of Pleistocene faunal remains.

This paper shows that combining dietary restriction of arginine and proline with polyamine depletion drugs enhances tumor differentiation and survival in a neuroblastoma mouse model by disrupting oncogenic translation.

The paper uses proteomics to identify personalized signatures of insulin resistance and type 2 diabetes, showing that fasting proteome and phosphoproteome predict insulin sensitivity and reveal sex-specific differences.

This study identifies ADAMTS-7 as a risk factor for atherosclerosis by degrading TIMP-1, reducing its inhibition of MMP-9 and promoting collagen degradation.

This study identifies FKBP2 as a proline isomerase involved in proinsulin folding, showing its role in preventing misfolding and apoptosis in β-cells.

The paper induces unscheduled DNA replication in G1-phase budding yeast, showing it leads to genome instability through head-to-tail replication fork collisions during subsequent S-phase.

The paper identifies two DOMINO isoforms in Drosophila that form distinct complexes with different functions: DOM-B acts like SWR1 by depositing H2A.V, while DOM-A acts like NuA4 by acetylating H4K12.

The paper identifies DPPA3 as a driver of genome-wide passive DNA demethylation in mammals, showing it can bypass TET protein requirements and function across species.