Maria Adelaida Duque Correa

This study establishes an in vitro system using caecaloids to recapitulate whipworm development, showing that larvae develop anatomical features and growth patterns similar to in vivo conditions.

This study shows that the human whipworm's host specificity is driven by the host microbiome, using a humanized-microbiota mouse model and metagenomic analysis.

This study identifies serine proteases as key mediators of whipworm egg hatching induced by bacterial contact, revealing bacterial and larval enzyme interactions.

This study uses 2-D organoids to show that parasitic nematodes and their secreted products affect host gene expression differently depending on their location at the intestinal epithelium.

This paper introduces a bioengineered platform for bilaterally accessible GI organoid monolayers, enabling improved observability and studies of epithelial dynamics and pathogen interactions.

This paper optimizes single-nuclei isolation and RNA sequencing for parasitic nematodes, improving yield and RNA quality across life stages and sexes.

The paper evaluates DNA extraction methods for whole genome sequencing of individual helminth eggs and larvae, showing successful sequencing for six of eight species tested.