Rodrigo Jiménez‐Saiz

This study shows DGKζ is essential for CD40-mediated immune synapse formation, mTORC1 signaling, and plasma cell differentiation in B cells.

This study identifies a distinct transcriptional program in mast cells during desensitization, showing it involves active reprogramming rather than passive hyporesponsiveness.

This study shows that gut and oral bacteria metabolize peanut allergens, affecting IgE-binding and anaphylaxis severity in allergic individuals.

This study shows that IgG-mediated allergic inflammation increases serum triglycerides and alters lipid metabolism in mice and humans.

This paper identifies a small molecule that modulates CXCR4 nanoclustering without affecting ligand binding, improving therapeutic potential over existing CXCR4 antagonists.

The study identifies IgE+ memory B cells in humans as rare and suggests their limited clinical utility in allergic disease.