Andrew J. Wood

The paper introduces universal donor plasmids for biallelic degron-tagging in mammalian cells and organoids using Cas9-induced double strand breaks and homology-independent repair.

This study compares how stabilizing versus overproducing target proteins affects PROTAC activity using β-catenin as a model.

The paper quantifies signalling effects of CTNNB1 mutations across cancer types and finds weakly activating mutations correlate with worse prognosis in hepatocellular carcinoma.

The paper shows that tag fusions can have tissue-specific effects on protein stability in transgenic mice, depending on the cell and tissue environment.

This paper develops CRISPR-engineered mouse lines for rapid and specific degradation of endogenous proteins in vivo, revealing stage-specific requirements for condensin complexes in lymphocyte division.

The paper shows heterochromatin slows CRISPR-Cas9 mutagenesis but does not affect repair outcomes, with mutagenesis inhibition depending on Cas9 exposure levels.