Izabela Mamede

This study shows that IgA suppresses epithelial proliferation and tumorigenesis by interacting with DMBT1, highlighting its role in maintaining mucosal homeostasis.

This study tracks intestinal CD4+ T cells from suckling to adulthood, showing they adopt a transient cytotoxic-regulatory state at weaning, influenced by microbiota and early-life commensals.

This study shows that colorectal cancers with different metastatic potential trigger distinct early T cell responses, with non-metastatic tumors inducing cytotoxic T cells and pro-metastatic tumors causing hypoactivated T cells.

This study compares HPV16 and HPV18 cervical cancers using gene expression data to identify genotype-specific host pathway alterations and viral gene expression programs.

The paper identifies six lncRNAs that regulate gene expression in trans in human iPSCs, revealing isoform-specific effects and a systemic response to doxycycline exposure.

This study investigates the molecular effects of SCN2A loss-of-function in patient-derived neurons, revealing NMD activation, isoform-specific dysregulation, and lncRNA network perturbations.

The paper identifies lncRNA expression signatures associated with Ebola vaccine-induced immunity using RNA-sequencing data from three human cohorts.

This study characterizes a new multidrug-resistant Acinetobacter baumannii isolate and evaluates the transcriptomic effects of a synthetic antimicrobial peptide in combination with meropenem.

This study shows that Oropouche virus strains cause microcephaly-like effects in brain organoids by disrupting neural development and inducing cell death and apoptosis.

The paper identifies gut bacteria-derived succinate as a key metabolite that promotes enteric nervous system regeneration after antibiotic-induced dysbiosis.

This study meta-analyzes 16S rRNA sequencing studies on gut microbiota and type 2 diabetes, finding significant heterogeneity but no consistent differences between diabetic and non-diabetic groups.

The paper introduces tidyomics, an ecosystem bridging Bioconductor and tidy R to streamline omic analysis using data from the Human Cell Atlas.

This study identifies that SARS-CoV-2 increases unproductive splicing isoforms of immune-related genes, potentially subverting antiviral responses.