Sajad Sofi

The paper identifies six lncRNAs that regulate gene expression in trans in human iPSCs, revealing isoform-specific effects and a systemic response to doxycycline exposure.

This paper shows that AURKB drives the dissolution of CIZ1-RNA assemblies from the inactive X chromosome during mitosis by phosphorylating CIZ1's C-terminal extensions, disrupting its RNA interactions.

This study identifies that elevated CIZ1 anchor domain fragments in early stage cancers disrupt SMACs, leading to epigenetic instability by destabilizing PRC1-dependent histone modifications.