Matthew L. Kutys

The paper uses ML to analyze morphological dynamics of hiPSC-derived endothelial cells under shear stress, identifying a bifurcation between two stable cell states.

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

This study identifies FAM83H as a regulator linking keratin organization to Notch signaling in epidermal morphogenesis, showing its role in keratinocyte differentiation and cell-cell adhesion.

This study identifies JCAD as a scaffold that links tight junction condensates to actin and RhoA, enabling endothelial barrier adaptation to inflammation.

StrataChip enables dynamic study of human epidermal morphogenesis by integrating microfluidics with single-cell RNA-sequencing and imaging, revealing transcriptional and mechanical transitions during stratification.

The paper identifies Scrib's role in organizing cortical actomyosin clusters to stabilize adherens junctions and support angiogenic sprouting.

The paper identifies a flow-specific Notch1 mechanotransduction pathway involving receptor polarization, endocytosis, and proteolytic activation in response to fluid shear stress.

The paper compares monomeric StayGold variants using protein nanocages in living cells, finding mStayGold is 3-fold brighter and more photostable than EGFP and other variants.

This study shows DCX stabilizes microtubules in growth cones, enabling neuron morphogenesis in soft environments by resisting actomyosin contractile forces.