Brendon M. Baker

This paper creates a 3D image atlas of lung injury dynamics in mice, identifying aberrant endothelial cell expansion that fails to form perfused vasculature as a key feature of pulmonary fibrosis.

This study shows that perivascular matrix densification promotes fibrosis by activating pro-inflammatory endothelial cells through a novel VE-cadherin-TGF-βR2 axis.

This study develops granular hydrogel composites (GHCs) that enable rapid revascularization of tissue grafts by promoting vascular network formation and integration with host vasculature.

This paper develops microporous immune-isolating capsules that restore dynamic hormone signaling in a mouse model of premature ovarian insufficiency by enabling size-selective diffusion of hormones.

This paper validates a CUBIC-based workflow for volumetric analysis of follicles and vasculature in human ovarian tissue, showing comparable follicle density to histology and detailed vascular morphometrics.

This study shows cPLA2α localizes to exosomes during neutrophil chemotaxis, linking nuclear deformation to LTB4 signaling and motility.

This study shows that MAP hydrogel encapsulation improves revascularization and endocrine function of transplanted ovarian tissue in a mouse model of primary ovarian insufficiency.

This study uses photo-crosslinking to induce early fibrotic changes in ex vivo tissue, showing how matrix stiffening affects cell behavior and fibrosis progression.

This study shows that DSP haploinsufficiency causes cell-cell adhesion failure in cardiomyopathy and that increasing DSP expression rescues this defect.

This study investigates how matrix stiffness and alignment affect the structure and contractility of engineered myocardial tissues made from iPSC-derived cardiomyocytes.

This study develops clickable PEGNB microbeads that enable suspension bioprinting and microvascular self-assembly for engineering hierarchical vasculature.