Shintaroh Kubo

The paper resolves the native structure of the Trichonympha centriole cartwheel using cryo-electron tomography, revealing a zigzag stacking pattern of SAS-6 tetramers and their role in structural stability and polarity.

This study identifies a tyrosination-dependent mechanism that enables dynein-2 to specifically bind the A-tubule of ciliary doublet microtubules, facilitating retrograde IFT.

This study uses CG-MD simulations to show that dynamin's GDP state induces conformational changes leading to membrane constriction.

This study uses hybrid simulations to show that side chain flexibility and angular mismatch enhance Fo motor rotation efficiency, with conserved structural features across species.

This study uses computational modeling and molecular dynamics simulations to elucidate the proton-transfer coupled rotation mechanism of MotAB in bacterial flagellar motors.

This study examines how alpha-tubulin acetylation affects doublet microtubule structure in Tetrahymena cilia using cryo-EM, MD, and mass spectrometry, finding small-scale structural changes and a link to phosphorylation.

The paper develops a kinetic model of cytoplasmic dynein's bipedal stepping motions, showing how different stepping patterns arise from ATP hydrolysis and conformational changes.