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The paper resolves the native structure of the Trichonympha centriole cartwheel using cryo-electron tomography, revealing a zigzag stacking pattern of SAS-6 tetramers and their role in structural stability and polarity.

CsMT provides a streamlined CryoSPARC workflow for cryo-EM reconstruction of microtubules, achieving high-resolution results with minimal manual intervention.

The paper investigates ribosome clusters in neuronal RNA granules, finding they contain stalled ribosomes and unique 3D structures that avoid quality-control mechanisms.

The paper presents a high-resolution structure of the ciliary tip central pair in Tetrahymena thermophila and identifies proteins that stabilize microtubules.

DomainFit identifies protein domains in low-resolution cryo-EM maps using AlphaFold2 models, revealing new proteins in cellular complexes.

This study examines how alpha-tubulin acetylation affects doublet microtubule structure in Tetrahymena cilia using cryo-EM, MD, and mass spectrometry, finding small-scale structural changes and a link to phosphorylation.