Author
University of North Carolina at Chapel HillORCID 0000-0002-0965-8760Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
John D. Sears, Durbadal Ojha, Sharon Taft-Benz…·Nathaniel J. Moorman
This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.
Mohammad Anwar Hossain, Abigail K. Mayo, Anirban Ghoshal…·Timothy Mark Willson
This study evaluates the species-dependent metabolism and pharmacokinetics of a covalent nsP2 protease inhibitor, showing rapid clearance in mice but antiviral efficacy, and suggests potential for human dosing.
Joseph W. Guarnieri, Michael J. Topper, Katherine Beigel…·Stephen B. Baylin
This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.
Joseph W. Guarnieri, Joseph M. Dybas, Hossein Fazelinia…·Douglas C. Wallace
This study investigates how SARS-CoV-2 infection affects mitochondrial gene expression in different tissues and disease stages, finding targeted inhibition in some organs and upregulation in others.