Wes Sanders

This study shows that deletion of UL33 from HCMV genome reduces lytic replication in epithelial cells by impairing Gq-dependent signaling and gene expression.

This study evaluates the virulence and replication of 12 no-known-vector flaviviruses (NKVFVs) in mice, showing that seven are lethal in immunocompromised mice and all replicate in mouse cells.

This paper develops a computational pipeline to identify conserved antiviral target sites in alphaviruses using AI-driven methods, validating potential drug targets through mutagenesis.

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

This study investigates how SARS-CoV-2 infection affects mitochondrial gene expression in different tissues and disease stages, finding targeted inhibition in some organs and upregulation in others.