Nathaniel J. Moorman

This study identifies a two-pronged mechanism by which CMX521 inhibits SARS-CoV-2 RNA-dependent RNA polymerase through biochemical assays and single-molecule techniques.

This study shows that deletion of UL33 from HCMV genome reduces lytic replication in epithelial cells by impairing Gq-dependent signaling and gene expression.

This study evaluates the virulence and replication of 12 no-known-vector flaviviruses (NKVFVs) in mice, showing that seven are lethal in immunocompromised mice and all replicate in mouse cells.

This study shows DHX29 is required for efficient translation of HCMV immediate early proteins IE1 and IE2, which are critical for viral replication and reactivation.

This paper develops a computational pipeline to identify conserved antiviral target sites in alphaviruses using AI-driven methods, validating potential drug targets through mutagenesis.

The paper describes the enantioselective resolution of a chemical probe targeting CHIKV nsP2 helicase, showing potent antiviral activity for one enantiomer and low activity for the other.

This study shows RNA ribosylation inhibits translation, decreases RNA stability, and activates antiviral immune responses in mammalian cells during chikungunya virus infection.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

The paper analyzes the transcriptional network of HCMV in latency by comparing gene expression with and without UL135 and UL138, revealing their roles in viral gene regulation and hematopoietic differentiation.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

This study evaluates the species-dependent metabolism and pharmacokinetics of a covalent nsP2 protease inhibitor, showing rapid clearance in mice but antiviral efficacy, and suggests potential for human dosing.

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

The paper identifies potent covalent inhibitors of Chikungunya nsP2 protease and establishes structure-activity relationships to guide inhibitor design.

The paper synthesizes pyrimidoquinoline derivatives as CSNK2A inhibitors with antiviral activity, finding that certain substituents improve potency while maintaining solubility.

This study identifies G9a's noncanonical role in promoting translation of genes involved in hyperinflammation and lymphopenia in COVID-19, revealing therapeutic targets that counteract viral effects.

This study investigates how SARS-CoV-2 infection affects mitochondrial gene expression in different tissues and disease stages, finding targeted inhibition in some organs and upregulation in others.

The paper identifies stochastic variability in viral tegument protein abundance as a mechanism for probabilistic bet hedging between viral replication and latency in herpesvirus.