Joshua N. Bembenek

The paper identifies linear elements formed by outer kinetochore proteins that regulate vesicle transport during anaphase I in C. elegans oocytes.

The paper investigates how securin degradation by APC/C controls separase localization and function during meiosis I, showing its role in chromosome segregation and exocytosis.

The paper functionally validates a de novo PPP5C variant in a human proband using C. elegans, showing it causes loss-of-function and is likely responsible for the patient's phenotypes.

The paper investigates cytokinesis variations during C. elegans embryonic morphogenesis and finds Aurora B kinase is essential for epithelial polarization and tissue formation.

The paper reanalyzes sequence conservation of separase's N-terminal domain, identifying a conserved cysteine-rich motif across nematodes and vertebrates.

This study identifies novel separase regulators in C. elegans through an ENU mutagenesis screen, revealing mutations in pph-5 and hsp-90 that suppress a separase mutant phenotype.

This study shows that separase protease activity is required for both chromosome segregation and RAB-11 vesicle exocytosis during cytokinesis, with protease-dead separase causing defects in both processes.