The paper identifies tRNAGly sequestration as a unifying mechanism causing GARS1-associated peripheral neuropathy and suggests therapeutic strategies to elevate tRNAGly levels.

7 citations

Drosophilaexperimental assay

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Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedNov 4, 2024

tRNA modification enzyme-dependent redox homeostasis regulates synapse formation and memory

Kimberly R. Madhwani, Shanzeh Sayied, Carlson H. Ogata…·Kate M. O’Connor-Giles

This study shows ALKBH8 regulates synaptic formation and memory via redox homeostasis in Drosophila by modulating selenoprotein synthesis and oxidative stress.

15 citations

Drosophilaexperimental assay

𝕏 PostBluesky

Developmental BiologyPLoS GeneticsPeer-reviewedApr 17, 2020

The Drosophila FUS ortholog cabeza promotes adult founder myoblast selection by Xrp1-dependent regulation of FGF signaling

Marica Catinozzi, Moushami Mallik, Marie Frickenhaus…·Erik Storkebaum

This study shows that the Drosophila FUS ortholog cabeza regulates founder myoblast selection via Xrp1-dependent FGF signaling, affecting muscle development.

5 citations

Drosophilaexperimental assay

𝕏 PostBluesky