Michael A. Davies

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

This study shows that oxidative phosphorylation (OXPHOS) is critical for melanoma metastasis to the lungs and brain, based on analysis of human patients and mouse models.

The paper tests imipridones in a mouse model of uveal melanoma, finding they reduce tumor growth and improve survival by targeting oxidative phosphorylation.

The paper identifies shared transcriptomic features between melanoma brain metastases and neurodegenerative diseases, highlighting key genes and providing an open-source tool for analysis.

This study identifies ARF6-dependent endocytic trafficking of the IFN-gamma receptor as a mechanism driving adaptive immune resistance in cancer, linking it to immune checkpoint blockade efficacy.

The paper presents a pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis of tumor regions and xenograft-transplant lymphoproliferative disorder prediction.

The paper compiles protein response data from cancer cell lines to drug perturbations, showing improved drug sensitivity prediction and building a protein-drug connectivity map with an accessible data portal.