Peter W. Baas

The paper analyzes the biophysical properties of exon 4a in tau proteins, showing it introduces a highly acidic, hydrophilic module that reduces aggregation potential compared to LMW tau.

This study uses isogenic hiPSC-derived motor cortical organoids to identify HDAC6 hyperactivation as a key driver of SPG4 pathology and a potential therapeutic target.

The paper shows tau and MAP6 have opposing roles in neuronal development by regulating microtubule stability and dynamics in cultured neurons and in vivo.

The paper shows that an ASD-linked mutation in Katnal2 impairs ependymal ciliary motion, causing hydrocephalus and behavioral deficits in mice.