Noriyuki Kinoshita

This study shows ZO-1 moves between tight junctions and podosomes during collective cell migration, regulated by ERK activity, and contributes to cell adhesion and movement.

The paper shows that ZO-1/ZO-2-deficient cells are selectively eliminated by cell competition, mediated by supracellular actomyosin cables and Hippo signaling, to maintain epithelial barrier homeostasis.

The paper demonstrates mechanical coupling between epithelial cells at apical-apical surfaces during implantation, mediated by extracellular matrix and tight junction molecules.