Author

Roshan Ghimire

Oklahoma State UniversityORCID 0000-0002-1397-3966Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Rakshya ShresthaiD· 2 shared Rudragouda ChannappanavariD· 2 shared Anthony R. FehriD· 1 shared Anuradha RoyiD· 1 shared Catherine M. KerriD· 1 shared Cody WhitleyiD· 1 shared David K. JohnsoniD· 1 shared Jessica J. PfannenstieliD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersImmunology

Rakshya ShresthaORCID

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2 papers

Recent·Most cited

ImmunologyPathogensPeer-reviewedNov 23, 2024

Differential TLR-ERK1/2 activity promotes viral ssRNA and dsRNA mimic-induced dysregulated immunity in macrophages

Rakshya Shrestha, Paige Johnson, Roshan Ghimire…·Rudragouda Channappanavar

This study shows that differential TLR-ERK1/2 activity drives dysregulated immunity in macrophages induced by viral RNA mimics.

5 citations

mousebulk RNA-seq

𝕏 PostBluesky

MicrobiologyJournal of VirologyPeer-reviewedOct 10, 2024

Mutation of a highly conserved isoleucine residue in loop 2 of several ????-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection

Catherine M. Kerr, Jessica J. Pfannenstiel, Yousef M. O. Alhammad…·Anthony R. Fehr

This study shows that mutating a conserved isoleucine in the macrodomain of MERS-CoV and SARS-CoV-2 enhances ADP-ribose binding but reduces viral replication and pathogenesis.

19 citationstop 3%

𝕏 PostBluesky