Author

Ananya A. Basu

Northwestern UniversityORCID 0000-0002-1427-5326Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Xiaoyu ZhangiD· 2 shared Alana G. CaldwelliD· 1 shared Anil VasudevaniD· 1 shared Assa MagassaiD· 1 shared Brayley S. GattisiD· 1 shared Chenlu ZhangiD· 1 shared Chenlu ZhangiD· 1 shared Felicia KoiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Xiaoyu ZhangORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintMar 7, 2025

Heterobifunctional proteomimetic polymers for targeted protein degradation

Max Mu Wang, Mihai Ioan Truica, Brayley S. Gattis…·Nathan C. Gianneschi

This paper introduces HYDRAC, a polymer-based platform for targeted protein degradation, demonstrating its effectiveness in degrading MYC and KRAS in vitro and in vivo.

DOI 10.1101/2025.03.07.641543

experimental assaydrug response / drug discovery

𝕏 PostBluesky

BiochemistryJournal of the American Chemical SocietyPeer-reviewedFeb 6, 2025

Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation

Ananya A. Basu, Chenlu Zhang, Milad Rouhimoghadam…·Xiaoyu Zhang

This study shows that the FBXW7 R465C somatic mutant can be used for targeted protein degradation via heterobifunctional compounds.

4 citations

experimental assay

𝕏 PostBluesky

BiochemistryNature Chemical BiologyPeer-reviewedJul 4, 2024

A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation

Ananya A. Basu, Chenlu Zhang, Isabella A. Riha…·Xiaoyu Zhang

This study identifies FBXO22 as an E3 ligase that supports ligand-induced protein degradation through PROTACs, expanding the toolkit for targeted protein degradation.

53 citationstop 2%

humangenetic perturbation / CRISPR

𝕏 PostBluesky