Author

Isabella A. Riha

Northwestern UniversityORCID 0009-0000-1278-498XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Chenlu ZhangiD· 2 shared Xiaoyu ZhangiD· 2 shared Alana G. CaldwelliD· 1 shared Ananya A. BasuiD· 1 shared Assa MagassaiD· 1 shared Chen ZhouiD· 1 shared Felicia KoiD· 1 shared M. Jamal Jenkins· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Chenlu ZhangORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedApr 10, 2026

Harnessing FBXO31 with terminal amide-functionalized molecules for targeted protein degradation

Chenlu Zhang, Xiaokang Jin, Chen Zhou…·Xiaoyu Zhang

This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.

1 citation

experimental assayprotein folding & dynamics

𝕏 PostBluesky

BiochemistryNature Chemical BiologyPeer-reviewedJul 4, 2024

A CRISPR activation screen identifies FBXO22 as an E3 ligase supporting targeted protein degradation

Ananya A. Basu, Chenlu Zhang, Isabella A. Riha…·Xiaoyu Zhang

This study identifies FBXO22 as an E3 ligase that supports ligand-induced protein degradation through PROTACs, expanding the toolkit for targeted protein degradation.

53 citationstop 2%

humangenetic perturbation / CRISPR

𝕏 PostBluesky