Chenlu Zhang

PROXINAUT automates hit-to-degrader discovery by integrating library screening with parallel synthesis, resulting in validated degraders with improved binding affinity.

This study develops a chemical proteomics platform to investigate covalent neoantigen formation and demonstrates immune cell recruitment through antibody-dependent cellular phagocytosis.

This paper demonstrates the use of FBXO31 as an E3 ligase for targeted protein degradation using amidated motifs, showing broader target degradation potential compared to CRBN-based degraders.

This study introduces a platform to map reactive cysteines on MHC-I-bound peptides and shows interferon-gamma increases reactivity at position 8 of 9-mer antigens.

This study identifies FBXO22 as an E3 ligase that supports ligand-induced protein degradation through PROTACs, expanding the toolkit for targeted protein degradation.

The paper identifies and evaluates transporters for improved xylodextrin utilization in yeast and discusses challenges in directed evolution.