Cameron S. Metcalf

This study evaluates the efficacy of stiripentol add-on to clobazam and valproic acid in a Scn1aA1783V/WT mouse model of Dravet syndrome, showing reduced seizure frequency and therapeutic plasma concentrations.

This study evaluates combination therapies for Dravet Syndrome using a mouse model, finding that triple-drug regimens enhance seizure control through potential drug interactions.

The paper evaluates the pharmacokinetics of antiseizure drugs in rodent models to assess their efficacy and duration of action.

This study shows that galanin agonists prevent seizure-induced respiratory arrest in mice, suggesting they could be a potential therapy for SUDEP.

This paper evaluates the pharmacoresistance of spontaneous seizures in an intra-amygdala kainate model of temporal lobe epilepsy to various antiseizure drugs, finding resistance to sodium channel inhibitors but sensitivity to GABA modulators and valproate.

This paper describes a moderate-throughput drug screening platform in a rat model of temporal lobe epilepsy to evaluate antiepileptogenic agents, finding no significant effect of everolimus or phenobarbital on preventing spontaneous recurrent seizures.