Author

David R. Mark

University of GlasgowORCID 0000-0002-1688-5224Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:E. coli· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Andrew J. RoeiD· 3 shared Rebecca E. McHughiD· 2 shared Arwen I. I. TyleriD· 1 shared Ester SerranoiD· 1 shared Gill R. DouceiD· 1 shared Iris FloriaiD· 1 shared Kabo R. WaleiD· 1 shared Mathew H. HorrocksiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersMicrobiology

Andrew J. RoeORCID

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3 papers

Recent·Most cited

BiophysicsOpen BiologyPeer-reviewedJun 1, 2025

AdhE spirosome length in enterohaemorrhagic Escherichia coli is correlated with enzymatic directionality and is perturbed by salicylidene acylhydrazide binding

Ester Serrano, Tianxiao Zhao, David R. Mark…·Olwyn Byron

This paper shows that ME0054 disrupts AdhE spirosomes, enhancing ethanol-to-acetyl-CoA conversion and altering T3SS expression in EHEC.

2 citations

E. coliproteomics

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MicrobiologyOpen BiologyPeer-reviewedNov 1, 2024

Aurodox, a polyketide from Streptomyces goldiniensis, inhibits transcription of the type III secretion system of multiple Gram-negative pathogens

David R. Mark, Nicky O’Boyle, Kabo R. Wale…·Andrew J. Roe

This study investigates aurodox's effect on T3SS in multiple Gram-negative pathogens, showing it inhibits some but not all T3SS systems, with selectivity observed across different strains.

3 citations

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MicrobiologybioRxivPreprintJul 5, 2024

The Enemy Within: how pathogen-free are your commercial specific pathogen-free mice?

David R. Mark, Mia Y Trolan, Gill R. Douce…·Rebecca E. McHugh

The paper isolates and characterizes an E. coli O157:H7 strain from commercial specific-pathogen-free mice, revealing limitations in current screening systems.

DOI 10.1101/2024.07.05.602177

mouseDNA methylation

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