Cheng Li

This study investigates FUS-ERG fusion oncoprotein-DNA co-condensates, revealing nested asymmetric phase separation and their potential for DNA-based information manipulation.

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

The paper uses biomolecular condensates to experimentally validate mass-conserving reaction-diffusion models for phase separation.

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

The paper compares single-cell regulomes of macaque and mouse neural progenitors with human data to identify evolutionary changes in cortex development.

The paper maps long-range enhancer networks in human, macaque, and mouse fetal cortex, showing human-specific enhancers and neuropsychiatric disorder-linked SNPs regulate gene expression during neurogenesis.

This study shows that breaking DNA-cell size scaling in E. coli leads to a linear growth regime and resource reallocation to plasmid-borne gene expression.

This study shows that transcription by Pol I, Pol II, and Pol III has minimal direct effect on 3D chromatin structure in mammalian cells, but indirect effects on chromatin accessibility and Cohesin occupancy are observed.

The paper characterizes 3D genome structure and chromatin accessibility in human tolerant T cells, identifying SOCS1 as a key regulator of tolerance.

This study investigates the role of lamin B1 in chromatin architecture and dynamics using imaging and Hi-C sequencing, finding that lamin B1 depletion leads to chromatin decompaction and increased inter-chromosomal interactions.